Malignant transformation of oral leukoplakia is associated with macrophage polarization

Table 2 Cell counts (positive cells/mm²) of CD68, CD163 and CD11c positive macrophages in OLP (group 1 and 2), OSCC (group 3) and healthy oral mucosa (group 4)

a) Macrophage cell count epithelial (cells/mm²)
Marker	n	CD68		CD11c		CD163
Marker	n	Median	SD	Median	SD	Median	SD
Group
1: transforming OLP	50	16	69	10	71	5	29
2: non-transforming OLP	53	8	21	2	12	0	7
3: OSCC	49	102	128	57	124	85	126
4: controls, healthy mucosa	49	5	10	5	26	2	11
p-values
Group 1 vs. 2		0.005		< 0.001		< 0.001
Group 1 vs. 3		< 0.001		< 0.001		<0.001
Group 1 vs. 4		< 0.001		0.113		0.065
Group 2 vs. 4		0.082		0.014		0.012
Group 3 vs. 4		< 0.001		< 0.001		< 0.001
Group 2 vs. 3		< 0.001		< 0.001		< 0.001

b) Macrophage cell count subepithelial (cells/mm²)
Marker	n	CD68		CD11c		CD163
Marker	n	Median	SD	Median	SD	Median	SD
Group
1: transforming OLP	50	172	237	39	94	138	145
2: non-transforming OLP	53	52	114	19	91	122	119
3: OSCC	49	185	205	124	214	418	241
4: controls, healthy mucosa	49	76	65	11	19	64	96
p-values
Group 1 vs. 2		< 0.001		0.036		0.664
Group 1 vs. 3		0.960		< 0.001		< 0.001
Group 1 vs. 4		< 0.001		< 0.001		0.014
Group 2 vs. 4		0.192		0.006		0.051
Group 3 vs. 4		< 0.001		< 0.001		< 0.001
Group 2 vs. 3		< 0.001		< 0.001		< 0.001

Data for the epithelial compartment (a) and the subepithelial compartment (b) are given. Values represent median, standard deviation (SD) and p-value (Mann–Whitney-U test, SPSS 22)

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