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Table 1 Demographic and histomorphologic characteristics of the study cohort (201 cases): transforming OLP (group 1), non-transforming OLP (group 2), corresponding OSCC cases of group 1 (group 3) and healthy oral mucosa (group 4)

From: Malignant transformation of oral leukoplakia is associated with macrophage polarization

 

Group 1: transforming OLP

Group 2: non-transforming OLP

Group 3: corresponding OSCC

Group 4: controls

n

% of cases

n

% of cases

n

% of cases

n

% of cases

Number of cases

50

 

53

 

49

 

49

 

Gender

 Male

32

64.0

28

52.8

32

65.3

30

61.2

 Female

18

36.0

25

47.2

17

34.7

19

38.8

Mean age

60.5 years (SD 11.81)

 

53.8 years (SD 12.80)

 

63.0 years (SD 11.64)

 

39.3 years (SD 19.26)

 

Age range

32–92 years

 

23–70 years

 

34–93 years

 

6–79 years

 

Dysplasia

 D0

30

60.0

39

73.6

    

 D1

9

18.0

13

24.5

    

 D2

7

14.0

1

1.9

    

 D3

4

8.0

      

T-status

 T1–T2

    

38

77.6

  

 T3–T4

    

4

8.2

  

 Cis

    

2

4.1

  

 Unknown

    

5

10.2

  

N-status

 N0

    

21

42.9

  

 N+

    

6

12.2

  

 Unknown

    

22

44.9

  

L-status

 L0

    

15

30.6

  

 L1

    

1

2.0

  

 Unknown

    

33

67.3

  

Pn-status

 Pn0

    

7

14.3

  

 Pn1

    

1

2.0

  

 Unknown

    

41

83.7

  

Grading

 G1

    

14

28.6

  

 G2

    

21

42.9

  

 G3

    

11

22.4

  

 Unknown

    

3

6.1

  

Clinical stage

 Early

    

17

34.7

  

 Late

    

9

18.4

  

 Unknown

    

21

42.9

  

 Cis

    

2

4.1

  
  1. For OLP patients (group 1 and 2), histomorphologic dysplasia classification is given. For OSCC patients (group 3), staging parameters (T-, N-, L-, Pn-status, grading, clinical UICC stage) are shown
  2. CIS carcinoma in situ, n number of cases, OLP oral leukoplakia, OSCC oral squamous cell carcinoma, SD standard deviation, T-status tumor size, N-status lymph node metastases, L-status lymph vessel invasion, Pn-status perineural invasion, grading histologic tumor grading