|
Variable
|
Healthy controls (n = 25)
|
CFS/ME (n = 45)
|
p-valuea
|
|---|
|
Age (years)
|
44.96 ± 1.30
|
46.41 ± 0.84
|
N.S.
|
|
BMI (kg/m2)
|
23.77 ± 0.61
|
24.59 ± 0.69
|
N.S.
|
|
SBP (mmHg)
|
115.2 ± 2.15
|
121.2 ± 1.99
|
0.057
|
|
DBP (mmHg)
|
74.45 ± 1.56
|
79.56 ± 1.38
|
0.022
|
|
HR (bpm)
|
67.71 ± 1.93
|
74.72 ± 1.21
|
0.002
|
|
NCQ
|
0.40 ± 0.15
|
10.11 ± 0.28
|
< 0.001
|
|
FIS-40
|
|
Global score (0–160)
|
17.12 ± 3.25
|
140.9 ± 1.79
|
< 0.001
|
|
Physical
|
4.60 ± 0.94
|
36.95 ± 0.39
|
< 0.001
|
|
Cognitive
|
4.48 ± 1.03
|
35.73 ± 0.66
|
< 0.001
|
|
Psychosocial
|
8.04 ± 1.46
|
68.27 ± 1.04
|
< 0.001
|
|
COMPASS-31
|
|
Global score (0–100)
|
27.31 ± 2.42
|
80.10 ± 2.91
|
< 0.001
|
|
Orthostatic intolerance
|
2.52 ± 0.25
|
7.45 ± 0.31
|
< 0.001
|
|
Vasomotor
|
0.48 ± 0.21
|
1.93 ± 0.24
|
< 0.001
|
|
Secretomotor
|
0.76 ± 0.18
|
4.73 ± 0.18
|
< 0.001
|
|
Gastrointestinal
|
5.60 ± 0.74
|
13.45 ± 0.68
|
< 0.001
|
|
Bladder
|
0.32 ± 0.11
|
3.48 ± 0.32
|
< 0.001
|
|
Pupillomotor
|
2.96 ± 0.46
|
10.32 ± 0.55
|
< 0.001
|
|
PSQI
|
|
Global score (0–21)
|
4.52 ± 0.63
|
15.05 ± 0.57
|
< 0.001
|
|
Subjective sleep quality
|
0.56 ± 0.12
|
2.23 ± 0.14
|
< 0.001
|
|
Sleep latency
|
0.72 ± 0.17
|
1.89 ± 0.16
|
< 0.001
|
|
Sleep duration
|
0.92 ± 0.17
|
2.05 ± 0.13
|
< 0.001
|
|
Habitual sleep efficiency
|
0.56 ± 0.22
|
1.95 ± 0.17
|
< 0.001
|
|
Sleep disturbances
|
1.04 ± 0.07
|
2.27 ± 0.13
|
< 0.001
|
|
Sleeping medication
|
0.28 ± 0.15
|
2.11 ± 0.19
|
< 0.001
|
|
Daytime dysfunction
|
0.44 ± 0.12
|
2.55 ± 0.11
|
< 0.001
|
|
HADS
|
|
Global score (0–42)
|
5.15 ± 0.70
|
26.68 ± 1.41
|
< 0.001
|
|
Anxiety
|
3.96 ± 0.41
|
13.73 ± 0.73
|
< 0.001
|
|
Depression
|
1.16 ± 0.29
|
12.95 ± 0.68
|
< 0.001
|
- Baseline self-reported measures scores (global and subscales) of symptoms, as explained in “Methods” section. Data are shown as mean ± SEM for each item
- aData were analyzed using Student’s t test for independent samples, and the Mann–Whitney U non-parametric test when appropriate
