Table 4 Multivariable analysis of risk factors for analyses examining PFS or OS for all-comers

PD-L1 expression high vs low^a

1.09

(0.78–1.52)

0.63

0.58

(0.30–1.13)

0.11

1.04

(0.79–1.37)

0.790

Age < 60 vs ≥ 60 years

0.89

(0.67–1.18)

0.40

0.82

(0.45–1.47)

0.50

0.71

(0.55–0.92)

0.008

Race Caucasian vs other

0.59

(0.38–0.9)

0.02

0.61

(0.30–1.23)

0.16

0.92

(0.62–1.37)

0.689

Nonsmoker vs current/former smoker

0.81

(0.55–1.21)

0.31

0.97

(0.47–2.01)

0.93

1.20

(0.85–1.69)

0.292

Heavy alcohol use, no vs yes

0.97

(0.57–1.66)

0.90

1.11

(0.39–3.14)

0.85

1.33

(0.80–2.19)

0.268

Metastatic disease, no vs yes

1.27

(0.96–1.68)

0.10

0.59

(0.34–1.03)

0.06

1.42

(1.10–1.84)

0.008

Platinum-based therapy, no vs yes

1.10

(0.68–1.79)

0.70

3.084

(0.64–14.81)

0.16

0.70

(0.52–0.94)

0.018

Anatomical site vs oral cavity

 Oropharynx

0.89

(0.59–1.35)

0.58

0.88

(0.39–1.99)

0.75

0.74

(0.52–1.05)

0.089

 Hypopharynx

0.65

(0.36–1.17)

0.15

0.72

(0.30–1.75)

0.47

0.62

(0.36–1.05)

0.076

 Larynx

0.74

(0.51–1.06)

0.10

0.88

(0.44–1.76)

0.72

0.63

(0.46–0.86)

0.003

 Overlapping lesion

1.05

(0.47–2.33)

0.91

0.82

(0.16–4.10)

0.81

1.25

(0.65–2.38)

0.503