Fig. 7

Pathway enrichment analysis of DEPs. a The screenshot of pathway enrichment analysis is shown. The top 20 enriched pathway terms are displayed. The P-value indicates the enrichment level of the pathway term and ranges from 0 to 1. A lesser P-value indicates greater intensiveness. Rich Factor is the ratio of the number of differentially expressed proteins annotated in the pathway term to all protein number annotated in this pathway term. A greater Rich Factor indicates greater intensiveness. b The network analysis of pathway terms. The ten purple balls represent the top 10 significant KEGG pathways. The red and blue balls represent the up- and down-regulated DEPs, respectively. The bigger ball represents the higher enrichment level of the relevant pathway. The edges with different colors represent the classes in the KEGG pathway analysis (sp number represents the swiss prot ID of the proteins; the gene name and species also showed on the ball; orange: metabolism; green: genetic information processing; purple: human disease)