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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: Phosphatidylcholine PC ae C44:6 in cerebrospinal fluid is a sensitive biomarker for bacterial meningitis

Fig. 1

PC ae C44:6 concentrations in CSF are highly elevated in bacterial meningitis. Concentrations were measured by mass spectrometry using cell-free CSF in samples from patients with bacterial meningitis (BacM, n = 32), Borrelia burgdorferi neuroborreliosis (Borrelia, n = 34), HSV encephalitis (HSE, n = 9), varicella zoster virus meningoencephalitis (VZV ME, n = 15), enterovirus meningitis (EntM, n = 10), facial zoster (VZV fac, n = 16), segmental zoster (VZV seg, n = 14), anti-NMDA-receptor autoimmune encephalitis (NMDA, n = 8), multiple sclerosis (MS, n = 17), Tourette syndrome (GTS, n = 20), Bell’s palsy (Bell, n = 11), and normal pressure hydrocephalus (NPH, n = 35). a Detection efficiency (% of samples with concentrations > LOD) of PC ae C44:6 in the 12 diagnoses. Detection rate was by far the highest in bacterial meningitis. b PC ae C44:6 concentrations across the 12 diagnoses. Median concentrations were highest in bacterial meningitis, but a considerable spread of values is evident within this group. c Higher median PC ae C44:6 concentrations in samples with CSF cell ≥ 5/μL. The boxes span the interquartile range (25–75th percentile), the circles define outlying values > 97.5th percentile. ***P < 0.001. d ROC analysis comparing PC ae C44:6 concentrations in samples with CSF cell count of 0–4 and ≥ 5/μL, demonstrating only a moderate association with neuroinflammation

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