TY - JOUR AU - de Araujo, Leonardo Silva AU - Pessler, Kevin AU - Sühs, Kurt-Wolfram AU - Novoselova, Natalia AU - Klawonn, Frank AU - Kuhn, Maike AU - Kaever, Volkhard AU - Müller-Vahl, Kirsten AU - Trebst, Corinna AU - Skripuletz, Thomas AU - Stangel, Martin AU - Pessler, Frank PY - 2020 DA - 2020/01/07 TI - Phosphatidylcholine PC ae C44:6 in cerebrospinal fluid is a sensitive biomarker for bacterial meningitis JO - Journal of Translational Medicine SP - 9 VL - 18 IS - 1 AB - The timely diagnosis of bacterial meningitis is of utmost importance due to the need to institute antibiotic treatment as early as possible. Moreover, the differentiation from other causes of meningitis/encephalitis is critical because of differences in management such as the need for antiviral or immunosuppressive treatments. Considering our previously reported association between free membrane phospholipids in cerebrospinal fluid (CSF) and CNS involvement in neuroinfections we evaluated phosphatidylcholine PC ae C44:6, an integral constituent of cell membranes, as diagnostic biomarker for bacterial meningitis. SN - 1479-5876 UR - https://doi.org/10.1186/s12967-019-02179-w DO - 10.1186/s12967-019-02179-w ID - de Araujo2020 ER -