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Fig. 7 | Journal of Translational Medicine

Fig. 7

From: ROR2 induces cell apoptosis via activating IRE1α/JNK/CHOP pathway in high-grade serous ovarian carcinoma in vitro and in vivo

Fig. 7

ROR2 overexpression suppressed HGSOC cell growth in vivo. a Images of mice with subcutaneous xenograft tumor. b Images of tumors transfected with PCMV-ROR2 or PCMV-NC. c Images of xenograft tumors’ HE staining. d The volumes of tumors with PCMV-ROR2 or PCMV-NC were measured and calculated every other day before the mice were sacrificed. The growth curves were analyzed using 2way ANOVA test. e, f The volume and weight of the formed tumors transfected with PCMV-ROR2 or PCMV-NC were compared using Student’s t test. g, h Western-blot assay and IHC assay were used to detect the protein levels of ROR2 in the formed tumors. β‑actin was used as a loading control in western-blot assay. The intensities of IHC staining were quantitated by Image-Pro Plus 6.0. IHC scores were analyzed with Student’s t test. *P < 0.05, **P < 0.01, ***P < 0.001 and ****P< 0.0001 for statistical analysis of the indicated groups

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