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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: A spontaneously metastatic model of bladder cancer: imaging characterization

Fig. 5

T2w MRI Coronal view including liver and xenograft. BL0293-F563 hepatic metastases as seen on MRI in a representative control animal without resection (a; left), aggravated (resected tumor) (b; middle), and an animal in the drug intervention group without tumor resection (c; right). Top row of coronal slices at day 36 post implant shows no evidence of metastatic disease on baseline MRI; however, 15 days later (52 days post implant) the same animal demonstrates numerous hepatic metastases in control and non-treated aggravated groups. The treated group demonstrated no evidence of metastases at day 74 and showed response of the primary tumor to the therapy (yellow arrows: BL0293 flank xenograft; red arrows: hepatic metastases). One animal in the drug treated group eventually developed hepatic metastases at 107 days, 2 weeks following a required excision of the xenograft post drug therapy due to ulceration

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