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Table 1 Some of the known gene mutations associated with IBD

From: Integrating omics for a better understanding of Inflammatory Bowel Disease: a step towards personalized medicine

Biological function Known genetic predisposition to:
CD UC Common to CD/UC
Maintain epithelial integrity MUC19, ITLN1 GNA12, HNF4A, CDH1, ERRFI1  
Paneth cells NOD2, LTLN1, ATG16L1   XBP1
Innate mucosal defense NOD2, ITLN1 SLC11A1, FCGR2A/B CARD9, REL
IL-23/Th17 STAT3 IL-21 IL-23R, JAK2, TYK2, ICOSLG, TNFSF15
Restitution STAT3 ERRFI1, HNF4A, PLA2G2A/E REL, PTGER4, NKX2-3
Immune tolerance IL-27, SBNO2, NOD2 IL1R1/IL1R2 IL-10, CREM
T-cell regulation NDFIP1, TAGAP, IL-2R IL-2, TNFRSF9, PIM3, IL-7R, TNFSF8, IFNG TNFSF8, IL-12B, IL-23, PRDM1, ICOSLG
B-cell regulation IL-5, IKZF1, BACH2 IL-7R, IRF5  
Solute transport SLC9A4, SLC22A5, SLC22A4 AQP12A/B, SLC9A3, SLC26A3  
Immune cell recruitment IL8RA/IL8RB CCL11, CCL2, CCL7, CCL8, CCR6 MST1
Antigen presentation ERAP2, LNPEP, DENND1B   
Autophagy NOD2, ATG16L1, IRGM PARK7, DAP CUL2
Oxidative/ER stress CAPEB4, PRDX5, BACH2, ADO, GPX1/3, SLC22A4, LRRK2, NOD2 SERINC3, HSPA6, DLD, PARK7 ORMDL3, XBP1, CARD9, UTS2, PEX13
Intracellular logistics VAMP3, FGFR1OP, FASLG, THADA TTLL8, CAP72, TPPP, ARPC2, LPS1, AAMP, DAP KIF21B, PUS10, MST1
Metabolism GCKR   SLC2A4RG