|
Maintain epithelial integrity
|
MUC19, ITLN1
|
GNA12, HNF4A, CDH1, ERRFI1
| |
|
Paneth cells
|
NOD2, LTLN1, ATG16L1
| |
XBP1
|
|
Innate mucosal defense
|
NOD2, ITLN1
|
SLC11A1, FCGR2A/B
|
CARD9, REL
|
|
IL-23/Th17
|
STAT3
|
IL-21
|
IL-23R, JAK2, TYK2, ICOSLG, TNFSF15
|
|
Restitution
|
STAT3
|
ERRFI1, HNF4A, PLA2G2A/E
|
REL, PTGER4, NKX2-3
|
|
Immune tolerance
|
IL-27, SBNO2, NOD2
|
IL1R1/IL1R2
|
IL-10, CREM
|
|
T-cell regulation
|
NDFIP1, TAGAP, IL-2R
|
IL-2, TNFRSF9, PIM3, IL-7R, TNFSF8, IFNG
|
TNFSF8, IL-12B, IL-23, PRDM1, ICOSLG
|
|
B-cell regulation
|
IL-5, IKZF1, BACH2
|
IL-7R, IRF5
| |
|
Solute transport
|
SLC9A4, SLC22A5, SLC22A4
|
AQP12A/B, SLC9A3, SLC26A3
| |
|
Immune cell recruitment
|
IL8RA/IL8RB
|
CCL11, CCL2, CCL7, CCL8, CCR6
|
MST1
|
|
Antigen presentation
|
ERAP2, LNPEP, DENND1B
| | |
|
Autophagy
|
NOD2, ATG16L1, IRGM
|
PARK7, DAP
|
CUL2
|
|
Oxidative/ER stress
|
CAPEB4, PRDX5, BACH2, ADO, GPX1/3, SLC22A4, LRRK2, NOD2
|
SERINC3, HSPA6, DLD, PARK7
|
ORMDL3, XBP1, CARD9, UTS2, PEX13
|
|
Intracellular logistics
|
VAMP3, FGFR1OP, FASLG, THADA
|
TTLL8, CAP72, TPPP, ARPC2, LPS1, AAMP, DAP
|
KIF21B, PUS10, MST1
|
|
Metabolism
|
GCKR
| |
SLC2A4RG
|
