Integrating omics for a better understanding of Inflammatory Bowel Disease: a step towards personalized medicine

Table 1 Some of the known gene mutations associated with IBD

Biological function	Known genetic predisposition to:
Biological function	CD	UC	Common to CD/UC
Maintain epithelial integrity	MUC19, ITLN1	GNA12, HNF4A, CDH1, ERRFI1
Paneth cells	NOD2, LTLN1, ATG16L1		XBP1
Innate mucosal defense	NOD2, ITLN1	SLC11A1, FCGR2A/B	CARD9, REL
IL-23/T_h17	STAT3	IL-21	IL-23R, JAK2, TYK2, ICOSLG, TNFSF15
Restitution	STAT3	ERRFI1, HNF4A, PLA2G2A/E	REL, PTGER4, NKX2-3
Immune tolerance	IL-27, SBNO2, NOD2	IL1R1/IL1R2	IL-10, CREM
T-cell regulation	NDFIP1, TAGAP, IL-2R	IL-2, TNFRSF9, PIM3, IL-7R, TNFSF8, IFNG	TNFSF8, IL-12B, IL-23, PRDM1, ICOSLG
B-cell regulation	IL-5, IKZF1, BACH2	IL-7R, IRF5
Solute transport	SLC9A4, SLC22A5, SLC22A4	AQP12A/B, SLC9A3, SLC26A3
Immune cell recruitment	IL8RA/IL8RB	CCL11, CCL2, CCL7, CCL8, CCR6	MST1
Antigen presentation	ERAP2, LNPEP, DENND1B
Autophagy	NOD2, ATG16L1, IRGM	PARK7, DAP	CUL2
Oxidative/ER stress	CAPEB4, PRDX5, BACH2, ADO, GPX1/3, SLC22A4, LRRK2, NOD2	SERINC3, HSPA6, DLD, PARK7	ORMDL3, XBP1, CARD9, UTS2, PEX13
Intracellular logistics	VAMP3, FGFR1OP, FASLG, THADA	TTLL8, CAP72, TPPP, ARPC2, LPS1, AAMP, DAP	KIF21B, PUS10, MST1
Metabolism	GCKR		SLC2A4RG

ISSN: 1479-5876