Fig. 6
Value of CXCL9, CXCL10, and CXCL11 for predicting HIV viral load and disease progression. a ROC curves for CXCL9, CXCL10, CXCL11, and the combination panel of three chemokines to evaluate their use for predicting viral load at set-point. AUC was used to evaluate viral load at set-point and the point with the maximum sum of sensitivity plus specificity was defined as the cutoff value. b Kaplan–Meier curves for CXCL9, CXCL10, CXCL11, and the combination panel of three chemokines. According to the cutoff value for chemokine expression levels, patients were divided into high expressers (above the cutoff value) and low expressers (below the cutoff value). Viral load reaching > 104 copies/mL was considered the end point of follow-up. p values for curves provided on graphs. c Kaplan–Meier curves for CXCL9, CXCL10, CXCL11, and the combination panel of three chemokines. According to the cutoff value of chemokine expression, patients were divided into high expressers (above the cutoff value) and low expressers (below the cutoff value). Viral load reaching > 104 copies/mL and CD4+ T-cell count reaching ≤ 500 cells/μL was considered the end point for follow-up. p values for curves provided on graphs. d Schematic and formula of the combined-chemokine-predictive model for HIV disease progression