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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Inflammatory processes and elevated osteoclast activity chaperon atrophic non-union establishment in a murine model

Fig. 3

Western blot verifies inflammatory reaction during non-union establishment. Western blots against Runx2, TNF-α, MMP13, RANKL and TGF-β. According to qRT-PCR results protein levels of Runx2 in non-unions seemed to be similar to control, except for early fracture healing, indicating a physiological osteoblastogenesis during non-union establishment. Moreover, RANKL mediated Osteoclast activity seemed to be upregulated during the whole non-union establishment process. This was accompanied by an inflammatory reaction, including TNF-α, MMP13 and TGF-β as central mediators. p-value: *< 0.05; ** < 0.01; ***< 0.001

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