Fig. 6
Correlation coefficients between the gut microbiome (Lactobacillus and Clostridium) relative abundance with learning and memory in Morris water maze. Correlation of aLactobacillus, bClostridium with time in the target quadrant, c PFC BDNF concentration with lactobacillus, d Hippocampal serotonin concentration with Clostridium. e Hippocampal BDNF level with time in the target quadrant. f PFC MDA level with time in the target quadrant. Relations between two variables were computed by Pearson correlation coefficients. D-Control diabetic control, D-Pro: diabetic + the L. plantarum, D-Pre diabetic + inulin, D-Syn diabetic the L. plantarum + inulin, D-Sham: diabetic sham group, BDNF brain-derived neurotrophic factor, TrkB tropomyosin receptor kinase B, CREB cyclic adenosine monophosphate responsive element-binding protein