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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: The regulatory effect of microRNA-21a-3p on the promotion of telocyte angiogenesis mediated by PI3K (p110α)/AKT/mTOR in LPS induced mice ARDS

Fig. 4

Expression of angiogenesis-related genes in TCs with LPS treatment. a mRNA levels of E2F8, Notch1, EPAS1, Rbpj, Flt1, ACVRL1, EFNB2, Thbs1, FLT1, miR-21a-3p and miR-221-5p in TCs treated with LPS and/or miR-21a-3p inhibitor or miR-221-5p inhibitor. *P < 0.05 vs Control, #P < 0.05 vs LPS. b Protein levels of E2F8 in TCs treated with LPS and/or miR-21a-3p inhibitor. *P < 0.05 vs Control, #P < 0.05 vs LPS. c MiR-21a-3p led to a significant reduction of the luciferase activity of reporter with the wildtype 3′ UTR but not that of the mutant reporter. *P < 0.05 vs E2F8-WT/miRNA miR-21a-3p mimic. n = 6

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