Fig. 3

Gdf11 gene transfer suppressed HFD-induced hyperinsulinemia and maintained glucose homeostasis. a Blood glucose levels with or without 6 h fasting of mice at the end of the feeding period. b Serum glucose level of mice in GTT (2 g glucose/kg, i.p.); c area under the curve of GTT; d Relative blood glucose level of mice in ITT (0.75 U/kg, i.p.); e blood insulin level; f results of HOMA-IR analysis for insulin resistance. Data represent mean ± SEM (n = 5). *P < 0.05 comparing to mice fed regular Chow, ^#P < 0.05 comparing to HFD-fed control animals