TY - JOUR AU - Dobrovolsky, A. P. AU - Gedzun, V. R. AU - Bogin, V. I. AU - Ma, D. AU - Ichim, T. E. AU - Sukhanova, Iu. A. AU - Malyshev, A. V. AU - Dubynin, V. A. PY - 2019 DA - 2019/12/03 TI - Beneficial effects of xenon inhalation on behavioral changes in a valproic acid-induced model of autism in rats JO - Journal of Translational Medicine SP - 400 VL - 17 IS - 1 AB - Xenon (Xe) is a noble gas that has been used for the last several decades as an anesthetic during surgery. Its antagonistic effect on glutamate subtype of NMDA (N-methyl-d-aspartate) receptors resulted in evaluation of this gas for treatment of CNS pathologies, including psychoemotional disorders. The aim of this study was to assess the behavioral effects of acute inhalation of subanesthetic concentrations of Xe and to study the outcomes of Xe exposure in valproic acid (VPA)-induced rodent model of autism. SN - 1479-5876 UR - https://doi.org/10.1186/s12967-019-02161-6 DO - 10.1186/s12967-019-02161-6 ID - Dobrovolsky2019 ER -