TY - JOUR AU - Melvin, A. AU - Lacerda, E. AU - Dockrell, H. M. AU - O’Rahilly, S. AU - Nacul, L. PY - 2019 DA - 2019/12/04 TI - Circulating levels of GDF15 in patients with myalgic encephalomyelitis/chronic fatigue syndrome JO - Journal of Translational Medicine SP - 409 VL - 17 IS - 1 AB - Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating condition characterised by fatigue and post-exertional malaise. Its pathogenesis is poorly understood. GDF15 is a circulating protein secreted by cells in response to a variety of stressors. The receptor for GDF15 is expressed in the brain, where its activation results in a range of responses. Among the conditions in which circulating GDF15 levels are highly elevated are mitochondrial disorders, where early skeletal muscle fatigue is a key symptom. We hypothesised that GDF15 may represent a marker of cellular stress in ME/CFS. SN - 1479-5876 UR - https://doi.org/10.1186/s12967-019-02153-6 DO - 10.1186/s12967-019-02153-6 ID - Melvin2019 ER -