From: The pathogenesis of renal injury and treatment in light chain deposition disease
Therapy | Study | Total | With MM | LC type | Age | Creatinine clearance (mL/min) | Median creatinine mg/dL | 24Â h urinary protein excretion | CR (%) | LC deposits | Surviving patients (%) | Median follow up (months) | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
κ | λ | Pre | Posta | Pre | Posta | ||||||||||
MEVP | Komatsuda [44] | 1 | 1 | 1 | 0 | 64 | 44 | 73 | 2.0 | 1.0 | Decease to less than 0.1 | 100 | 0 | 100 | 70 |
BD | Kastritis [47] | 4 | 0 | 3 | 1 | 57.85 (range 46–67) | – | – | 2.9 | 1.9 | Reduction 89.5% | 50 | 2/4 | 100 | 11.3 (range 2–16) |
HDM + ASCT | Kastritis [47] | 3 | 0 | 3 | 0 | 51.3 (range 46–56) | – | – | – | – | Only trace proteinuria | 100 | – | 100 | 14.3 (range 12–16) |
After BD | González –López [23] | 1 | 0 | 1 | 0 | 63 | 17 | 50 | 5.2 | 2.31 | – | 100 | 0 | 100 | 54 |
Tovar [24] | 3 | 0 | 1 | 2 | 49 (range 46–56) | – | – | 2.14 | 1.27 | Reduction 84% | 67 | 0 | 100 | 28.7 (range 12–40) | |
ASCT after CBD | Smita [48] | 1 | 0 | 1 | 0 | 33 | – | – | 4.9 | 1.60 | – | 100 | 0 | 100 | 12 |
and VLD | Weichman [40] | 5 | 0 | 3 | 2 | 44.5 (range 36–51) | – | – | 55 | 2 patients HD/PD | Reduction 75.3% | 80 | 0 | 100 | 12 (range 4–29) |
HDM + ASCT | Lorenz [46] | 6 | 3 | 5 | 1 | 43.5 (33–61) | – | – | 2.4 | 1 patient HD | Reduction 92% | 100 | – | 83.3 | 31.7 |
Pozzi [4] | 5 | 4 | – | – | 58 ± 14.2 | – | – | – | 1 patient uremia | – | – | – | 100 | 27.5 |