Fig. 6
The mechanism map depicting that BZRAP1-AS1 promotes the progression of HCC through down-regulation of THBS1 via recruiting DNMT3b. BZRAP1-AS1, highly expressed in HCC, binds to the promoter of THBS1, recruits the DNMT3b, and enhances the methylation of THBS1 promoter, thus inhibiting the transcription of THBS1. THBS1 depletion promotes angiogenesis via increasing VEGFA and CD31 expression. HCC hepatocellular carcinoma, BZRAP1-AS1 BZRAP1-antisense RNA 1, THBS1 thrombospondin1