| N | Median PFS (in months) | Univariable Analysis | Multivariable Analysis | ||
---|---|---|---|---|---|---|
HR (95% CI) | p-value | HR (95% CI) | p-value | |||
Age | 52 | 16.24 | 0.95 (0.91, 1.00) | 0.06 | Â | Â |
BMI | 52 | 16.24 | 0.90 (0.82, 0.98) | 0.02 | 0.87 (0.79, 0.96) | 0.007 |
Smoking history | ||||||
 No | 27 | 13.28 | 1.00 | Ref |  |  |
 Yes | 25 | 18.48 | 0.80 (0.39, 1.67) | 0.55 |  |  |
Nephrectomy | ||||||
 Total | 44 | 16.24 | Ref | Ref |  |  |
 Partial | 3 | – | 0.31 (0.04, 2.45) | 0.27 |  |  |
 None | 5 | 18.48 | 0.83 (0.25, 2.78) | 0.76 |  |  |
ICI line of treatment | ||||||
 First line | 5 | – | 1.00 | Ref |  |  |
 Second line | 23 | 18.48 | 1.73 (0.37, 8.08) | 0.49 |  |  |
 Third line | 17 | 13.28 | 2.65 (0.54, 13.04) | 0.23 |  |  |
 Fourth line | 5 | 20.52 | 2.08 (0.32, 13.56) | 0.44 |  |  |
 > 4 prior treatments | 2 | 25.71 | 0.83 (0.07, 9.45) | 0.88 |  |  |
ECOG PS at start of immunotherapy | ||||||
 0 | 19 | 16.24 | 1.00 | Ref |  |  |
 1 or 2 or 3 | 32 | 18.48 | 0.83 (0.38, 1.79) | 0.63 |  |  |
 Missing | 1 | – | – | – |  |  |
IMDC risk score | ||||||
 Favorable | 13 | 16.44 | 1.00 | Ref |  |  |
 Intermediate | 32 | 14.83 | 1.43 (0.58, 3.53) | 0.44 |  |  |
 Poor | 3 | 26.86 | 0.29 (0.04, 2.38) | 0.25 |  |  |
Occurrence of irAE | ||||||
 No | 33 | 10.13 | 1.00 | Ref | 1.00 | Ref |
 Yes | 19 | 20.52 | 0.42 (0.17, 0.99) | 0.04 | 0.33 (0.13, 0.82) | 0.02 |