Fig. 2

Landscape of T cell-inflamed and angiogenesis gene signature expression and association with survival in TCGA-ccRCC cohort (n = 517). a Primary tumor samples were categorized into non-T cell-inflamed (blue), T cell-inflamed (red), and intermediate (grey) group based on the expression of T cell-inflamed gene signature. Tumors are shown on the column, and sorted from low to high T cell-inflamed gene expression (left to right). Upper heatmap: T cell-inflamed gene expression; bottom heatmap: angiogenesis gene expression. Gene clusters are shown as dendrogram to the left of each heatmap. b Correlation of T cell-inflamed and angiogenesis gene signature expression in tumor groups. c Expression of T cell-inflamed and angiogenesis gene signatures in neoplasm histologic grade I to IV. Grade X samples were excluded (n = 4). e Comparison of survival distributions between patient groups split by quartiles of angiogenesis gene signature expression. PFI = progression-free interval event. OS = overall survival. Q1 to Q4 = expression quartile 1 to 4. Student’s t-test was used in c, followed by BH-FDR correction for multiple testing. Log-rank test was used in d