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Table 1 Clinical and biochemical characteristics of the studied subjects

From: Downregulation of exosomal miR-192-5p and miR-204-5p in subjects with nonclassic apparent mineralocorticoid excess

Clinical and biochemical parameters

NC-AME

Controls

n

10

15

Female,  %

60% (6/10)

53.3% (8/15)

Age, years

24.4 [12.3–42.7]

25.8 [12.1–47.13]

BMI, kg/m2

27.3 [22.0–28.9]

24.6 [21.0–28.9]

SBP, mmHg

126.5 [110.3–154.1]

124.3 [108.0–143.3]

DBP, mmHg

73.8 [66.6–84.4]

78.0 [68.3–85.0]

Aldosterone, ng/dl

8.9 [4.7–13.5]

12.7 [7.4–15.6]

PRA, ng/ml*h

1.2 [0.7–2.2]

2.1 [1.5–3.5]

Serum K+, mEq/l

4.0 [3.8–4.4]

4.5 [4.1–4.8]*

Serum Cortisol, µg/dl

12.5 [9.4–13.8]

8.1 [7.8–12.1]

Serum Cortisone, µg/dl

1.9 [1.8–2.1]

3.0 [2.5–3.1]*

Serum F/E ratio

6.0 [4.6–6.7]

3.1 [2.3–4.2]*

FEK 24 h  %

7.9 [6.0–9.0]

5.9 [4.7–7.2]*

Urinary sodium excretion, mEq/24 h

138.5 [54.5–215.8]

128.0 [71.0–199.0]

Urinary potassium excretion, mEq/24 h

49.0 [35.8–72.3]

53.0 [35.0–60.0]

Urinary Na+/K+ ratio

2.1 [1.4–3.7]

2.6 [1.9–3.8]

TTKG

5.6 [4.4–7.2]

4.4 [3.5–4.9]

Urinary F/E ratio

0.5 [0.4–0.5]

0.3 [0.3–0.4]*

(THF + allo-THF)/THE ratio

0.7 [0.6–0.8]

0.6 [0.5–0.9]

  1. Values correspond to median [Q1–Q3]
  2. BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, PRA plasma renin activity, K+ potassium, F cortisol, E cortisone, FEK fractional excretion of potassium, Na+ sodium, TTKG trans-tubular potassium gradient, THF tetrahydrocortisol; THE tetrahydrocortisone
  3. * p < 0.05, Mann–Whitney test