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Table 2 RHD alleles found among donors with a serologic weak D phenotype

From: Molecular and computational analysis of 45 samples with a serologic weak D phenotype detected among 132,479 blood donors in northeast China

Sample number RHD allele Occurrence frequency (%) Phenotype annotation Nucleotide change Amino acid substitution Haplotype Hybrid Rhesus box results ISBT terminology References
1–16 Weak D type 15 16 (35.6) Weak D c.845G > A p.G282D cDE/CDE/CDe RHD+/RHD RHD*15 [35]
17 Weak D type 15
RHD 1227A
1 (2.2) Weak D c.845G > A
c.1227G > A
p.G282D
p.K409K
CDe RHD+/RHD+ RHD*15
RHD*01EL.01
[35, 36]
18 Weak D type 18 1 (2.2) Weak D c.19C > T p.R7W CDe RHD+/RHD RHD*01 W.18 [37]
19 Weak D type 25 1 (2.2) Weak D c.341G > A p.R114Q CDe RHD+/RHD RHD*01 W.25 [38]
20 Weak D type 31 1 (2.2) Weak D c.17C > T p.P6L CDe RHD+/RHD RHD*01W.31 [39]
21 Weak D type 54 1 (2.2) Weak D c.365C > T p.S122L CDe RHD+/RHD RHD*01W.54 [38]
22 Weak D type 72 1 (2.2) Weak D c.1212C > A p.D404E CDe RHD+/RHD RHD*01W.72  
23 Weak D type 72
RHD 1227A
1 (2.2) Weak D c.1212C > A
c.1227G > A
p.D404E
p.K409K
CDe RHD+/RHD+ RHD*01W.72
RHD*01EL.01
[36]
24 RHD weak D 763C
RHD 1227A
1 (2.2) Weak D c.763G > C
c.1227G > A
p.G255R
p.K409K
CDe RHD+/RHD+ RHD*01EL.01 [36]
25 RHD weak D 101G
Weak D type 15
1 (2.2) Weak D c.101A > G
c.845G > A
p.Y34C
p.G282D
CDe RHD+/RHD+ RHD*15 [25, 35]
26 RHD weak D 399C
RHD 1227A
1 (2.2) Weak D c.399G > C c.1227G > A p.K133N p.K409K CDe RHD+/RHD+ RHD*01EL.01 [36]
27 RHD weak D 779G
RHD 1227A
1 (2.2) Weak D c.779A > G
c.1227G > A
p.H260R p.K409K CDE RHD+/RHD+ RHD*01EL.01 [25, 36]
28–29 RHD weak D 1102A 2 (4.4) Weak D c.1102G > A p.G368R CDe RHD+/RHD  
30 weak D type 61 1 (2.2) DEL c.28C > T p.R10W CDe RHD+/RHD RHD*01 W.61 [40]
31–33 RHD 1227A 3 (6.7) DEL c.1227G > A p.K409K CDe/CDE RHD+/RHD RHD*01EL.01 [36]
34 DFR type2 1 (2.2) Partial D RHD (D1-3 CE4 D5-10) CDe RHD+/RHD RHD*17.02 [41]
35–37 D V type 2 3 (6.7) Partial D RHD (D1-4CE3-5 D6-10) cDE/CDE RHD+/RHD RHD*05.02 [42]
38–44 DVI type 3 7 (15.6) Partial D RHD (D1-2-CE3-6-D7-10) CDe RHD+/RHD RHD*06.03 [43]
45 DVI type 4 1 (2.2) Partial D RHD (D1-2 CE3-5 D6-10) CDe RHD+/RHD RHD*06.04 [44]
  1. ISBT International Society of Blood Transfusion