Table 2 RHD alleles found among donors with a serologic weak D phenotype
Sample number | RHD allele | Occurrence frequency (%) | Phenotype annotation | Nucleotide change | Amino acid substitution | Haplotype | Hybrid Rhesus box results | ISBT terminology | References |
|---|---|---|---|---|---|---|---|---|---|
1–16 | Weak D type 15 | 16 (35.6) | Weak D | c.845G > A | p.G282D | cDE/CDE/CDe | RHD+/RHD− | RHD*15 | [35] |
17 | Weak D type 15 RHD 1227A | 1 (2.2) | Weak D | c.845G > A c.1227G > A | p.G282D p.K409K | CDe | RHD+/RHD+ | RHD*15 RHD*01EL.01 | |
18 | Weak D type 18 | 1 (2.2) | Weak D | c.19C > T | p.R7W | CDe | RHD+/RHD− | RHD*01 W.18 | [37] |
19 | Weak D type 25 | 1 (2.2) | Weak D | c.341G > A | p.R114Q | CDe | RHD+/RHD− | RHD*01 W.25 | [38] |
20 | Weak D type 31 | 1 (2.2) | Weak D | c.17C > T | p.P6L | CDe | RHD+/RHD− | RHD*01W.31 | [39] |
21 | Weak D type 54 | 1 (2.2) | Weak D | c.365C > T | p.S122L | CDe | RHD+/RHD− | RHD*01W.54 | [38] |
22 | Weak D type 72 | 1 (2.2) | Weak D | c.1212C > A | p.D404E | CDe | RHD+/RHD− | RHD*01W.72 |  |
23 | Weak D type 72 RHD 1227A | 1 (2.2) | Weak D | c.1212C > A c.1227G > A | p.D404E p.K409K | CDe | RHD+/RHD+ | RHD*01W.72 RHD*01EL.01 | [36] |
24 | RHD weak D 763C RHD 1227A | 1 (2.2) | Weak D | c.763G > C c.1227G > A | p.G255R p.K409K | CDe | RHD+/RHD+ | RHD*01EL.01 | [36] |
25 | RHD weak D 101G Weak D type 15 | 1 (2.2) | Weak D | c.101A > G c.845G > A | p.Y34C p.G282D | CDe | RHD+/RHD+ | RHD*15 | |
26 | RHD weak D 399C RHD 1227A | 1 (2.2) | Weak D | c.399G > C c.1227G > A | p.K133N p.K409K | CDe | RHD+/RHD+ | RHD*01EL.01 | [36] |
27 | RHD weak D 779G RHD 1227A | 1 (2.2) | Weak D | c.779A > G c.1227G > A | p.H260R p.K409K | CDE | RHD+/RHD+ | RHD*01EL.01 | |
28–29 | RHD weak D 1102A | 2 (4.4) | Weak D | c.1102G > A | p.G368R | CDe | RHD+/RHD− |  |  |
30 | weak D type 61 | 1 (2.2) | DEL | c.28C > T | p.R10W | CDe | RHD+/RHD− | RHD*01 W.61 | [40] |
31–33 | RHD 1227A | 3 (6.7) | DEL | c.1227G > A | p.K409K | CDe/CDE | RHD+/RHD− | RHD*01EL.01 | [36] |
34 | DFR type2 | 1 (2.2) | Partial D | RHD (D1-3 CE4 D5-10) | CDe | RHD+/RHD− | RHD*17.02 | [41] | |
35–37 | D V type 2 | 3 (6.7) | Partial D | RHD (D1-4CE3-5 D6-10) | cDE/CDE | RHD+/RHD− | RHD*05.02 | [42] | |
38–44 | DVI type 3 | 7 (15.6) | Partial D | RHD (D1-2-CE3-6-D7-10) | CDe | RHD+/RHD− | RHD*06.03 | [43] | |
45 | DVI type 4 | 1 (2.2) | Partial D | RHD (D1-2 CE3-5 D6-10) | CDe | RHD+/RHD− | RHD*06.04 | [44] | |