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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: Molecular and computational analysis of 45 samples with a serologic weak D phenotype detected among 132,479 blood donors in northeast China

Fig. 2

Comparison of the tertiary structure of modeled wild-type and mutant RhD proteins. RHD and D variant tertiary structures were modeled using Deep View-Swiss-Pdb Viewer 4.0.1. Helices are shown as deep pink and rose pink ribbons, sheets as yellow and orange, and coils as green. a1, b1, c1, and d1 are wild-type RhD protein. The weak D proteins of weak D type 31 (a2), weak D type 18 (a3), weak D type 61 (a4), weak D 101G (b2), weak D type 25 (b3), weak D 399C (b4), weak D type 54 (c2), weak D type 763C (c3) , weak D type15 (c4), weak D779G (d2), weak D 1102A (d3), and weak D type 72 (d4) compared with the left wild-type RhD proteins, respectively. The partial D proteins of DVI type 3 (e1), DVI type 4 (e2), D V type 2 (e3) and DFR type2 (e4) compared with the wild-type RhD protein (a1), respectively. The mutant weak D proteins (p.P6L, p.R7W, p.R10W, p.Y34C, p. R114Q, p.K133N, p.S122L, p.G255R, p.G280D, p.H260R, p.G368R and p.D404E) are highlighted

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