Fig. 1

Identification of miRNA signature for response to neoadjuvant chemotherapy (NAC) through a microarray-based miRNA expression profiling. a A heatmap of the identified 62-miRNA signature differentially expressed between responder and non-responder to NAC. b miR-23a-5p expression levels in serum specimens taken from responders and non-responders to NAC. c miR-193b-5p expression levels in serum specimens taken from responders and non-responders to NAC. d miR-873-3p expression levels in serum specimens taken from responders and non-responders to NAC. d Correlation analysis of expression levels of miR-23a-5p, miR-193b-5p, and miR873-3p. Correlations among three miRNAs were expressed as Spearman’s rank correlation values. e Recurrence-free survival stratified by expression level of miR-873-3p. Statistical comparison was based on log-rank test. R responder, NR non-responder