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Fig. 7 | Journal of Translational Medicine

Fig. 7

From: Exosomes of pasteurized milk: potential pathogens of Western diseases

Fig. 7

Dairy milk exosomes and atherogenesis. Milk exosomes are taken up by monocytes and macrophages. miR-148a stimulates the differentiation of monocytes to macrophages, especially of macrophages of the pro-inflammatory M1 type. miR-148a-mediated suppression of low density-lipoprotein (LDL) receptor (LDLR) expression increases circulating LDLs that after ageing-dependent chemical modifications are scavenged by macrophages. miR-148a-mediated suppression of ATP binding cassette transporter 1 (ABCA1) attenuates reverse cholesterol transport and thus further promotes lipid accumulation in macrophages. miR-148a-mediated suppression of DNA methyltransferase 1 (DNMT1) enhances the expression of adipose differentiation-related protein (ADRP) further promoting foam cell formation

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