Fig. 14
From: Exosomes of pasteurized milk: potential pathogens of Western diseases
Dairy milk exosomes and tumorigenesis of diffuse large B-cell lymphoma. miR-155 levels are significantly upregulated in diffuse large B-cell lymphoma (DLBCL). Epstein Barr Virus (EBV) infection in DLBCL induces miR-155 expression, which attenuates the expression of suppressor of cytokine signaling 1 (SOCS1). Loss-of-function mutations of SOCS1 (SOCS1*) have also been found in DLBCL further reducing SOCS1. Milk exosomes via transfer of miR-155 and miR-155-inducing transforming growth factor-β (TGF-β) may further promote tumorigenesis of DLBCL