Fig. 10
From: Exosomes of pasteurized milk: potential pathogens of Western diseases
Dairy milk exosomes and colorectal cancer prevention. DNA methyltransferase 1 (DNMT1) and Rho-associated coiled coil-containing protein kinase 1 (ROCK1) are overexpressed in colorectal cancer (CRC) cells. DNMT1 is regarded as a tumor promoter in CRC. Milk exosome uptake by CRC intestinal epithelial cells (IEC) increases intracellular levels of miR-148a, which suppresses DNMT1 and ROCK1, a potential mechanism explaining CRC prevention by consumption of pasteurized milk