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Fig. 10 | Journal of Translational Medicine

Fig. 10

From: Exosomes of pasteurized milk: potential pathogens of Western diseases

Fig. 10

Dairy milk exosomes and colorectal cancer prevention. DNA methyltransferase 1 (DNMT1) and Rho-associated coiled coil-containing protein kinase 1 (ROCK1) are overexpressed in colorectal cancer (CRC) cells. DNMT1 is regarded as a tumor promoter in CRC. Milk exosome uptake by CRC intestinal epithelial cells (IEC) increases intracellular levels of miR-148a, which suppresses DNMT1 and ROCK1, a potential mechanism explaining CRC prevention by consumption of pasteurized milk

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