Fig. 1

PRAME expression in common malignancies and association with survival in breast cancer. a PRAME mRNA expression across the most common human malignancies comparing expression in tumor (T, red) and normal (N, grey) tissue. Boxplot represents Median and IQR. *p ≤ 0.05, One-way ANOVA with log₂FC cutoff ≥ 1.5 or ≤ − 1.5. SKCM, Skin Cutaneous Melanoma; BRCA, breast invasive carcinoma; COAD, colon adenocarcinoma; LUAD, lung adenocarcinoma; LUSC, lung squamous cell carcinoma; LAML, acute myeloid leukemia. b Kaplan–Meier curves for overall and disease-free survival of PRAME expression in breast cancer. Patients were classified into subgroups with low (n = 531) or high (n = 534) expression defined as lower or as higher than median PRAME mRNA expression. p-value obtained by log-rank test