H2S target | Cell/tissue type | Functions | References |
---|---|---|---|
Akt | Cardiac, renal, neural, hepatic | JNK, mTOR, GSK3β, NR2A and B activation | |
HSP | Retinal, hepatic | Thioredoxin-1 activation, ROS scavenging, reducing inflammatory cytokine induction | |
JNK | Cardiac, retinal, renal, hepatic, epithelial | Bcl-2 inactivation, cytochrome C release | |
Beclin-1 | Cardiac, hepatic | Decrease autophagosome formation | |
GSK3β | Cardiac, hepatic, neural | Activate Bax, decrease LC3 and Beclin-1, inhibit mPTP opening, | |
Bcl-2 | Cardiac, renal, hepatic, neural, epithelial | Prevent cytochrome C release, inactivate Bax | |
TNFα, IL-6, IL-1β | Cardiac, skeletal muscle, lung | ROS increase, mPTP opening, Bax activation | |
miRNA (1, 21, 485-5p) | Cardiac, neural | Reduce LDH, regulate transcriptional activation, reduce TNFα activity |