Fig. 1

Roles of H₂S in modulating Akt signaling pathways involved in ischemia reperfusion injury and recovery. H₂S activates PI3 K and downstream Akt phosphorylation, which can also be activated by mTORC2. Akt can subsequently activate mTORC1 to regulate protein synthesis and cell proliferation, eNOS to activate vascularization by VEGF, and induce phosphorylation of FoxO₃ to prevent activation of genes promoting autophagy and ubiquitination