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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Complement factors C3a and C5a mimick a proinflammatory microenvironment and increase HBV IGRA sensitivity

Fig. 4

Additional stimulation of whole blood with C3a and C5a improves IFNγ release assay sensitivity. IFNγ responses to HBsAg were assessed in presence of a, b C3a, c, d C5a as well as e, f C3a and C5a. Shown are for each condition a, c, e receiver-operating-characteristic (ROC) curves including calculated AUC (area under the curve) as well as b, d, f scatter plot of IFNγ release of HepB vaccinated and unvaccinated HC after stimulation of whole blood. All depicted values were corrected by the negative control. Dotted line indicates IFNγ cut-off at b 25.95 pg/ml (n = 78; n = 27 anti-HBs positive and n = 51 anti-HBs negative), d 103.5 pg/ml (n = 74; n = 22 anti-HBs positive and n = 52 anti-HBs negative), f 88.6 pg/ml (n = 55; n = 17 anti-HBs negative and n = 38 anti-HBs positive)

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