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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Complement factors C3a and C5a mimick a proinflammatory microenvironment and increase HBV IGRA sensitivity

Fig. 3

HBsAg-specific IFNγ and IL2 production depict the hepatitis B vaccination status. a IFNγ and b IL2 responses were assessed upon stimulation of whole blood with HBsAg. Shown are for each cytokine a, c receiver-operating-characteristic (ROC) curves including calculated AUC (area under the curve) as well as b, d scatter plot of cytokine release of HepB vaccinated and unvaccinated HC after stimulation of whole blood. All depicted values were corrected by the negative control. Dotted line indicates b IFNγ cut-off at 28.45 pg/ml and d IL2 cut-off at 3.8 pg/ml (n = 87; n = 28 anti-HBs negative and n = 59 anti-HBs positive)

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