Fig. 3
Chromatin and functional context of DNA methylation changes. a Heatmaps depicting significant (p < 0.05) enrichment of hyper- and hypomethylated 0 → 5 dmCpG sites with different histone marks, in a selection of 21 different blood tissue and cell types (see Additional file 7: Table S3 for 98 full cell and tissue types, and also 5 → 10 dmCpG enrichments). The color code indicates the significant enrichment based on the odds ratio (OR). b Heatmaps displaying significant (p < 0.05) enrichment of hyper- and hypomethylated 0 → 5 dmCpG sites with different chromatin states, in a selection of 21 different blood tissue and cell types (see Additional file 8: Table S4 for 98 full cell and tissue types, and also 5 → 10 dmCpG enrichments). The color code indicates the significant enrichment based on the OR. c Heatmaps showing significant (p < 0.05) enrichment of hyper- and hypomethylated 0 → 5 dmCpG sites with predicted enhancers in 65 different cell and tissue types (see Additional file 9: Table S5 for full data, and also 5 → 10 dmCpG enrichments). The color code indicates the significant enrichment based on the OR. d Treemap plots indicating the results of REViGO semantic analyses of significantly enriched (FDR < 0.05) gene ontology biological process terms for genes containing 0 → 5 dmCpGs. In total, 402 and 345 significant terms were found for hyper- and hypomethylated dmCpGs, respectively (see Additional file 4: Table S6 for full results, including molecular function and cellular component terms, and also 5 → 10 dmCpG enrichments)