Biomarkers from circulating neutrophil transcriptomes have potential to detect unruptured intracranial aneurysms

Table 2 Gene ontology (GO) analysis

Category	GO term	Description	p-value	q-value
Transcripts with higher expression in intracranial aneurysms (IA)
Process	GO:0031347	Regulation of defense response	5.11E−06	0.0658
Process	GO:0050727	Regulation of inflammatory response	1.01E−05	0.0652
Process	GO:0019934	cGMP-mediated signaling	3.77E−05	0.162
Process	GO:0032101	Regulation of response to external stimulus	3.90E−05	0.125
Process	GO:0031348	Negative regulation of defense response	4.45E−05	0.115
Process	GO:0050728	Negative regulation of inflammatory response	5.21E−05	0.112
Process	GO:0007165	Signal transduction	6.64E−05	0.122
Function	GO:0004908	Interleukin-1 receptor activity	2.25E−06	0.00858
Function	GO:0004872	Receptor activity	7.22E−05	0.138
Function	GO:0060089	Molecular transducer activity	7.22E−05	0.092
Function	GO:0038023	Signaling receptor activity	1.32E−04	0.127
Transcripts with lower expression in IA
Function	GO:0043295	Glutathione binding	1.16E−04	0.148
Function	GO:0046906	Tetrapyrrole binding	1.40E−04	0.134

Gene set enrichment analysis was performed on the 95 significantly differentially expressed genes (q < 0.05) in peripheral blood samples obtained from patients with intracranial aneurysms (IA). Significantly enriched ontologies with a false discovery rate (FDR) adjusted p-value (q-value) < 0.20 were considered (FDR of 20%). Transcripts with higher expression in IA demonstrated regulation of inflammatory and defense responses, signaling, and cell motility. Significantly enriched ontologies in transcripts with lower expression in IA demonstrated regulation of glutathione and tetrapyrrole binding

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