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Table 2 Gene ontology (GO) analysis

From: Biomarkers from circulating neutrophil transcriptomes have potential to detect unruptured intracranial aneurysms

Category GO term Description p-value q-value
Transcripts with higher expression in intracranial aneurysms (IA)
 Process GO:0031347 Regulation of defense response 5.11E−06 0.0658
 Process GO:0050727 Regulation of inflammatory response 1.01E−05 0.0652
 Process GO:0019934 cGMP-mediated signaling 3.77E−05 0.162
 Process GO:0032101 Regulation of response to external stimulus 3.90E−05 0.125
 Process GO:0031348 Negative regulation of defense response 4.45E−05 0.115
 Process GO:0050728 Negative regulation of inflammatory response 5.21E−05 0.112
 Process GO:0007165 Signal transduction 6.64E−05 0.122
 Function GO:0004908 Interleukin-1 receptor activity 2.25E−06 0.00858
 Function GO:0004872 Receptor activity 7.22E−05 0.138
 Function GO:0060089 Molecular transducer activity 7.22E−05 0.092
 Function GO:0038023 Signaling receptor activity 1.32E−04 0.127
Transcripts with lower expression in IA
 Function GO:0043295 Glutathione binding 1.16E−04 0.148
 Function GO:0046906 Tetrapyrrole binding 1.40E−04 0.134
  1. Gene set enrichment analysis was performed on the 95 significantly differentially expressed genes (q < 0.05) in peripheral blood samples obtained from patients with intracranial aneurysms (IA). Significantly enriched ontologies with a false discovery rate (FDR) adjusted p-value (q-value) < 0.20 were considered (FDR of 20%). Transcripts with higher expression in IA demonstrated regulation of inflammatory and defense responses, signaling, and cell motility. Significantly enriched ontologies in transcripts with lower expression in IA demonstrated regulation of glutathione and tetrapyrrole binding