Fig. 5

Comparison of fold-change in expression in patients with “small” (< 5 mm) IAs vs. control and patients with “large” (≥ 5 mm) IAs vs. control. The plot shows the fold-change (F-C) in expression of the 26 classifier transcripts identified in the training cohort (n = 30—black line) compared to those for “small” IAs (vs. control—green) and “large” IAs (vs. control—orange). Expression changes were more pronounced in both the positive and negative direction in patients with larger IAs. Fold-changes across all 26 transcripts in the “large” group were on average 24% higher than those for the training cohort, while fold-changes for the “small” group F-C were on average 35% lower