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Table 3 Univariable and multivariable Cox regression analysis of the PCG-lncRNA signature and survival of GBM patients

From: Identification of a multidimensional transcriptome signature for survival prediction of postoperative glioblastoma multiforme patients

Variables

Univariable analysis

Multivariable analysis

HR

95% CI of HR

P

HR

95% CI of HR

P

 

Lower

Upper

  

Lower

Upper

 

The training set

 Age

  > 60 vs. ≤ 60

1.54

0.9

2.64

0.12

1.96

0.98

3.92

0.06

 Sex

  Male vs. female

0.68

0.39

1.2

0.18

0.65

0.33

1.28

0.21

 KPS

  > 70 vs. ≤ 70

0.86

0.42

1.74

0.04

2.48

1.05

5.87

0.04

 The signature

  High risk vs. low risk

4.68

2.48

8.80

< 0.001

5.94

2.66

13.25

< 0.001

The test set

 Age

  > 60 vs. ≤ 60

1.93

1.05

3.56

0.04

1.66

0.81

3.44

0.16

 Sex

  Male vs. female

0.8

0.45

1.43

0.45

1.16

0.52

2.59

0.71

 KPS

  > 70 vs. ≤ 70

0.51

0.25

1.07

0.08

0.53

0.24

1.17

0.12

 The signature

  High risk vs. low risk

2.77

1.49

5.16

0.001

2.89

1.35

6.20

0.01

The independent set

 Age

  > 60 vs. ≤ 60

1.65

0.92

2.96

0.09

1.54

0.85

2.79

0.15

 Sex

  Male vs. female

0.92

0.53

1.61

0.77

1.05

0.59

1.85

0.88

 The signature

  High risk vs. low risk

2.24

1.22

4.11

0.01

2.17

1.16

4.07

0.02

The entire TCGA set

 MGMT

  Methylated vs. unmethylated

0.92

0.48

1.77

0.80

0.94

0.49

1.83

0.87

 IDH1

  R132H vs. WT

0.27

0.04

2.01

0.20

0.46

0.06

3.57

0.46

 The signature

  High risk vs. low risk

4.00

1.97

8.12

< 0.001

3.71

1.80

7.62

< 0.001

  1. KPS Karnofsky performance score
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Journal of Translational Medicine

ISSN: 1479-5876

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