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Table 3 Cox regression analysis for overall survival in 205 pancreatic cancer patients

From: FGFR1 expression defines clinically distinct subtypes in pancreatic cancer

  P value HR Univariate Analysis P value HR Multivariate analysis
95.0% CI for HR 95.0% CI for HR
Lower Upper Lower upper
Age, years (≥ 60 vs. < 60) 0.016 1.451 1.073 1.961 0.008 1.587 1.130 2.230
Gender 0.235 1.191 0.892 1.591     
Tumor size, cm (≥ 2 vs. < 2) 0.241 1.534 0.751 3.135     
Differentiation (well/moderate vs. poor) 0.076 1.428 0.964 2.115     
Extension (confined vs. peripancreatic soft tissue) 0.061 1.898 0.970 3.714     
Bile duct invasion (absent vs. present) 0.009 1.469 1.099 1.963 0.002 1.657 1.211 2.269
Duodenum invasion (absent vs. present) 0.074 1.303 0.975 1.742     
Lymphovascular invasion (absent vs. present) 0.011 1.455 1.088 1.944 0.098 1.320 .950 1.834
Perineural invasion (absent vs. present) 0.086 1.403 .953 2.064     
Lymph node metastasis (absent vs. present) < 0.001 2.495 1.811 3.436 < 0.0001 2.360 1.665 3.344
Tumor stagea 0.059 1.382 0.988 1.933     
FGFR1 (positive vs. negative) 0.003 0.590 0.415 0.839 0.035 0.677 0.471 0.972
  1. aTumor stage was not included for multivariate analysis because tumor size, in addition to bile duct and duodenal invasion and extension (confined vs peripancreatic soft tissue extension), are components of T stage