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Table 3 Cox regression analysis for overall survival in 205 pancreatic cancer patients

From: FGFR1 expression defines clinically distinct subtypes in pancreatic cancer

 

P value

HR

Univariate Analysis

P value

HR

Multivariate analysis

95.0% CI for HR

95.0% CI for HR

Lower

Upper

Lower

upper

Age, years (≥ 60 vs. < 60)

0.016

1.451

1.073

1.961

0.008

1.587

1.130

2.230

Gender

0.235

1.191

0.892

1.591

    

Tumor size, cm (≥ 2 vs. < 2)

0.241

1.534

0.751

3.135

    

Differentiation (well/moderate vs. poor)

0.076

1.428

0.964

2.115

    

Extension (confined vs. peripancreatic soft tissue)

0.061

1.898

0.970

3.714

    

Bile duct invasion (absent vs. present)

0.009

1.469

1.099

1.963

0.002

1.657

1.211

2.269

Duodenum invasion (absent vs. present)

0.074

1.303

0.975

1.742

    

Lymphovascular invasion (absent vs. present)

0.011

1.455

1.088

1.944

0.098

1.320

.950

1.834

Perineural invasion (absent vs. present)

0.086

1.403

.953

2.064

    

Lymph node metastasis (absent vs. present)

< 0.001

2.495

1.811

3.436

< 0.0001

2.360

1.665

3.344

Tumor stagea

0.059

1.382

0.988

1.933

    

FGFR1 (positive vs. negative)

0.003

0.590

0.415

0.839

0.035

0.677

0.471

0.972

  1. aTumor stage was not included for multivariate analysis because tumor size, in addition to bile duct and duodenal invasion and extension (confined vs peripancreatic soft tissue extension), are components of T stage