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Table 4 Multivariate survival analyses of prognostic factors associated with OS and DFS for OSCC

From: Preoperative systemic immune-inflammation index predicts prognosis of patients with oral squamous cell carcinoma after curative resection

Variables OS DFS
HR [95% CI]ª Pª HR [95% CI]ª Pª
Training cohort
 SII (≥ 484.5, < 484.5) 3.887 (1.358–11.126) 0.011 2.814 (1.242–6.375) 0.013
 NLR (≥ 2.9, < 2.9) 3.114 (1.148–8.446) 0.026 2.328 (1.000–5.422) 0.050
 PLR (≥ 170.2, < 170.2) 5.678 (2.130–15.135) 0.001 3.318 (1.414–7.788) 0.006
Validation cohort
 SII (≥ 484.5, < 484.5) 2.188 (1.326–3.610) 0.002 2.322 (1.444–3.732) 0.001
 NLR (≥ 2.9, < 2.9) 1.982 (1.150–3.416) 0.014 2.015 (1.204–3.373) 0.008
 PLR (≥ 170.2, < 170.2) 2.697 (1.628–4.466) < 0.001 2.496 (1.538–4.050) < 0.001
Combined cohort
 SII (≥ 484.5, < 484.5) 2.885 (1.845–4.511) < 0.001 2.767 (1.842–4.157) < 0.001
 NLR (≥ 2.9, < 2.9) 2.458 (1.547–3.903) < 0.001 2.305 (1.499–3.543) < 0.001
 PLR (≥ 170.2, < 170.2) 3.203 (2.071–4.954) < 0.001 2.600 (1.727–3.912) < 0.001
  1. HR hazard ratio, CI confidence interval
  2. ªAdjusted for age, gender, smoking, alcohol use, tumor size, pathological grade, cervical nodal metastasis, clinical stage in logistic regression models