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Table 3 Univariate survival analyses of prognostic factors associated with OS and DFS for OSCC

From: Preoperative systemic immune-inflammation index predicts prognosis of patients with oral squamous cell carcinoma after curative resection

Variables OS DFS
HR [95% CI] P HR [95% CI] P
Training cohort
 Age (> 60, ≤ 60) 0.991 (0.395–2.485) 0.985 1.223 (0.559–2.676) 0.614
 Gender (male, female) 1.344 (0.536–3.369) 0.529 2.067 (0.919–4.650) 0.079
 Smoking (yes, no) 0.570 (0.207–1.568) 0.276 0.983 (0.467–2.068) 0.983
 Alcohol use (yes, no) 0.832 (0.278–2.488) 0.742 1.610 (0.752–3.445) 0.220
 Tumor size (T3–T4, T1–T2) 3.772 (1.561–9.117) 0.003 2.713 (1.322–5.566) 0.006
 Pathological grade (II–III, I) 1.691 (0.704–4.063) 0.240 1.466 (0.715–3.004) 0.296
 Cervical nodal metastasis (N+, N0) 1.653 (0.600–4.550) 0.331 2.219 (1.012–4.869) 0.047
 Clinical stage (III–IV, I–II) 2.214 (0.921–5.325) 0.076 2.634 (1.279–5.422) 0.009
 SII (≥ 484.5, < 484.5) 5.089 (2.027–12.775) 0.001 3.309 (1.609–6.805) 0.001
 NLR (≥ 2.9, < 2.9) 4.270 (1.775–10.271) 0.001 3.031 (1.456–6.312) 0.003
 PLR (≥ 170.2, < 170.2) 4.493 (1.859–10.854) 0.001 2.397 (1.096–5.242) 0.029
Validation cohort
 Age (> 60, ≤ 60) 1.001 (0.607–1.651) 0.996 0.974 (0.609–1.559) 0.912
 Gender (male, female) 1.124 (0.690–1.833) 0.639 1.071 (0.676–1.698) 0.769
 Smoking (Yes, No) 0.779 (0.416–1.458) 0.779 0.882 (0.459–1.473) 0.510
 Alcohol use (Yes, No) 1.143 (0.610–2.141) 0.677 1.100 (0.603–2.005) 0.757
 Tumor size (T3–T4, T1–T2) 1.073 (0.582–1.976) 0.821 1.084 (0.602–1.954) 0.787
 Pathological grade (II–III, I) 2.039 (1.247–3.334) 0.005 1.789 (1.125–2.844) 0.014
 Cervical nodal metastasis (N+, N0) 1.137 (0.663–1.949) 0.641 1.116 (0.662–1.883) 0.680
 Clinical stage (III–IV, I–II) 1.209 (0.733–1.994) 0.457 1.148 (0.707–1.864) 0.576
 SII (≥ 484.5, < 484.5) 2.348 (1.439–3.832) 0.001 2.431 (1.525–3.876) < 0.001
 NLR (≥ 2.9, < 2.9) 2.101 (1.263–3.496) 0.004 2.072 (1.275–3.369) 0.003
 PLR (≥ 170.2, < 170.2) 2.633 (1.610–4.307) < 0.001 2.423 (1.508–3.893) < 0.001
Combined cohort
 Age (> 60, ≤ 60) 0.971 (0.626–1.507) 0.897 0.998 (0.669–1.490) 0.992
 Gender (male, female) 1.090 (0.710–1.674) 0.693 1.192 (0.805–1.764) 0.380
 Smoking (yes, no) 0.598 (0.351–1.018) 0.058 0.750 (0.477–1.177) 0.210
 Alcohol use (yes, no) 0.942 (0.547–1.623) 0.830 1.143 (0.718–1.819) 0.573
 Tumor size (T3–T4, T1–T2) 1.439 (0.897–2.309) 0.131 1.387 (0.898–2.142) 0.140
 Pathological grade (II–III, I) 1.913 (1.248–2.933) 0.003 1.609 (1.093–2.369) 0.016
 Cervical nodal metastasis (N + , N0) 1.337 (0.833–2.145) 0.229 1.410 (0.915–2.172) 0.119
 Clinical stage (III–IV, I–II) 1.437 (0.935–2.208) 0.098 1.462 (0.987–2.166) 0.058
 SII (≥ 484.5, < 484.5) 3.037 (1.973–4.673) < 0.001 2.801 (1.896–4.138) < 0.001
 NLR (≥ 2.9, < 2.9) 2.587 (1.672–4.005) < 0.001 2.378 (1.588–3.562) < 0.001
 PLR (≥ 170.2, < 170.2) 3.250 (2.116–4.993) < 0.001 2.545 (1.703–3.803) < 0.001
  1. HR hazard ratio, CI confidence interval