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Table 3 Univariate survival analyses of prognostic factors associated with OS and DFS for OSCC

From: Preoperative systemic immune-inflammation index predicts prognosis of patients with oral squamous cell carcinoma after curative resection

Variables

OS

DFS

HR [95% CI]

P

HR [95% CI]

P

Training cohort

 Age (> 60, ≤ 60)

0.991 (0.395–2.485)

0.985

1.223 (0.559–2.676)

0.614

 Gender (male, female)

1.344 (0.536–3.369)

0.529

2.067 (0.919–4.650)

0.079

 Smoking (yes, no)

0.570 (0.207–1.568)

0.276

0.983 (0.467–2.068)

0.983

 Alcohol use (yes, no)

0.832 (0.278–2.488)

0.742

1.610 (0.752–3.445)

0.220

 Tumor size (T3–T4, T1–T2)

3.772 (1.561–9.117)

0.003

2.713 (1.322–5.566)

0.006

 Pathological grade (II–III, I)

1.691 (0.704–4.063)

0.240

1.466 (0.715–3.004)

0.296

 Cervical nodal metastasis (N+, N0)

1.653 (0.600–4.550)

0.331

2.219 (1.012–4.869)

0.047

 Clinical stage (III–IV, I–II)

2.214 (0.921–5.325)

0.076

2.634 (1.279–5.422)

0.009

 SII (≥ 484.5, < 484.5)

5.089 (2.027–12.775)

0.001

3.309 (1.609–6.805)

0.001

 NLR (≥ 2.9, < 2.9)

4.270 (1.775–10.271)

0.001

3.031 (1.456–6.312)

0.003

 PLR (≥ 170.2, < 170.2)

4.493 (1.859–10.854)

0.001

2.397 (1.096–5.242)

0.029

Validation cohort

 Age (> 60, ≤ 60)

1.001 (0.607–1.651)

0.996

0.974 (0.609–1.559)

0.912

 Gender (male, female)

1.124 (0.690–1.833)

0.639

1.071 (0.676–1.698)

0.769

 Smoking (Yes, No)

0.779 (0.416–1.458)

0.779

0.882 (0.459–1.473)

0.510

 Alcohol use (Yes, No)

1.143 (0.610–2.141)

0.677

1.100 (0.603–2.005)

0.757

 Tumor size (T3–T4, T1–T2)

1.073 (0.582–1.976)

0.821

1.084 (0.602–1.954)

0.787

 Pathological grade (II–III, I)

2.039 (1.247–3.334)

0.005

1.789 (1.125–2.844)

0.014

 Cervical nodal metastasis (N+, N0)

1.137 (0.663–1.949)

0.641

1.116 (0.662–1.883)

0.680

 Clinical stage (III–IV, I–II)

1.209 (0.733–1.994)

0.457

1.148 (0.707–1.864)

0.576

 SII (≥ 484.5, < 484.5)

2.348 (1.439–3.832)

0.001

2.431 (1.525–3.876)

< 0.001

 NLR (≥ 2.9, < 2.9)

2.101 (1.263–3.496)

0.004

2.072 (1.275–3.369)

0.003

 PLR (≥ 170.2, < 170.2)

2.633 (1.610–4.307)

< 0.001

2.423 (1.508–3.893)

< 0.001

Combined cohort

 Age (> 60, ≤ 60)

0.971 (0.626–1.507)

0.897

0.998 (0.669–1.490)

0.992

 Gender (male, female)

1.090 (0.710–1.674)

0.693

1.192 (0.805–1.764)

0.380

 Smoking (yes, no)

0.598 (0.351–1.018)

0.058

0.750 (0.477–1.177)

0.210

 Alcohol use (yes, no)

0.942 (0.547–1.623)

0.830

1.143 (0.718–1.819)

0.573

 Tumor size (T3–T4, T1–T2)

1.439 (0.897–2.309)

0.131

1.387 (0.898–2.142)

0.140

 Pathological grade (II–III, I)

1.913 (1.248–2.933)

0.003

1.609 (1.093–2.369)

0.016

 Cervical nodal metastasis (N + , N0)

1.337 (0.833–2.145)

0.229

1.410 (0.915–2.172)

0.119

 Clinical stage (III–IV, I–II)

1.437 (0.935–2.208)

0.098

1.462 (0.987–2.166)

0.058

 SII (≥ 484.5, < 484.5)

3.037 (1.973–4.673)

< 0.001

2.801 (1.896–4.138)

< 0.001

 NLR (≥ 2.9, < 2.9)

2.587 (1.672–4.005)

< 0.001

2.378 (1.588–3.562)

< 0.001

 PLR (≥ 170.2, < 170.2)

3.250 (2.116–4.993)

< 0.001

2.545 (1.703–3.803)

< 0.001

  1. HR hazard ratio, CI confidence interval
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Journal of Translational Medicine

ISSN: 1479-5876

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