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Table 2 Associations between SII and multiple clinicopathological parameters in OSCC

From: Preoperative systemic immune-inflammation index predicts prognosis of patients with oral squamous cell carcinoma after curative resection

Variable SII
Training cohort Validation cohort Combined cohort
< 484.5 ≥ 484.5 P < 484.5 ≥ 484.5 P < 484.5 ≥ 484.5 P
No. of patients 96 42   105 66   201 108  
Age (y)
 ≤ 60 36 11 0.197 38 27 0.536 74 38 0.776
 > 60 60 31   67 39   127 70  
Gender
 Male 53 28 0.208 51 39 0.180 104 67 0.083
 Female 43 14   54 27   97 41  
Smoking
 No 61 28 0.724 83 50 0.614 144 78 0.914
 Yes 35 14   22 16   57 30  
Alcohol use
 No 70 34 0.313 90 51 0.158 160 85 0.853
 Yes 26 8   15 15   41 23  
Tumor size
 T1–T2 78 25 0.007 88 47 0.049 166 72 0.002
 T3–T4 18 17   17 19   35 36  
Pathological grade
 I 61 22 0.218 63 32 0.140 124 54 0.047
 II–III 35 20   42 34   77 54  
Cervical nodal metastasis
 N0 78 34 0.967 73 48 0.654 151 82 0.876
 N+ 18 8   32 18   50 26  
Clinical stage
 I–II 65 26 0.508 65 35 0.252 130 61 0.157
 III–IV 31 16   40 31   71 47  
  1. The italic values in the table denotes P-values less than 0.05 with statistical significance