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Table 3 Clinical scores of patients with or without FH mutation

From: Application of expanded genetic analysis in the diagnosis of familial hypercholesterolemia in patients with very early-onset coronary artery disease

 

FH mutation (n = 40)

No FH mutation (n = 65)

p value

Simon Broome criteria

 Unlikely FH

25 (62.5%)

62 (95.4%)

 

 Possible FH

7 (17.5%)

1 (1.5%)

 

 Definite FH

8 (20.0%)

2 (3.1%)

 

 (Possible and definite)

15 (37.5%)

3 (4.6%)

< 0.001

Dutch Lipid Clinic criteria

 Unlikely FH

3 (7.5%)

25 (38.5%)

 

 Possible FH

14 (35.0%)

35 (53.8%)

 

 Probable FH

11 (27.5%)

1 (1.5%)

 

 Definite FH

12 (30.0%)

4 (6.2%)

 

 (Probable and definite)

23 (57.5%)

5 (7.7%)

< 0.001

  1. Data are expressed as n (%). FH familial hypercholesterolemia