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Table 3 Clinical scores of patients with or without FH mutation

From: Application of expanded genetic analysis in the diagnosis of familial hypercholesterolemia in patients with very early-onset coronary artery disease

  FH mutation (n = 40) No FH mutation (n = 65) p value
Simon Broome criteria
 Unlikely FH 25 (62.5%) 62 (95.4%)  
 Possible FH 7 (17.5%) 1 (1.5%)  
 Definite FH 8 (20.0%) 2 (3.1%)  
 (Possible and definite) 15 (37.5%) 3 (4.6%) < 0.001
Dutch Lipid Clinic criteria
 Unlikely FH 3 (7.5%) 25 (38.5%)  
 Possible FH 14 (35.0%) 35 (53.8%)  
 Probable FH 11 (27.5%) 1 (1.5%)  
 Definite FH 12 (30.0%) 4 (6.2%)  
 (Probable and definite) 23 (57.5%) 5 (7.7%) < 0.001
  1. Data are expressed as n (%). FH familial hypercholesterolemia
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