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Table 2 Biochemical and clinical characteristics of patients with different mutations

From: Application of expanded genetic analysis in the diagnosis of familial hypercholesterolemia in patients with very early-onset coronary artery disease

Characteristics

FH mutation (n = 40)

No FH mutation (n = 65)

p value

Age, years

29.9 ± 7.57

32.78 ± 3.70

0.029

Male, n (%)

35 (87.5)

64 (98.5)

0.019

BMI, kg/(m2)

25.16 ± 5.06

31.35 ± 24.85

0.133

Family history of premature CAD, n (%)

9 (22.5)

11 (16.9)

0.480

History of MI, n (%)

21 (52.5)

31 (47.7)

0.632

Currently smoking, n (%)

20 (50.0)

50 (76.9)

0.004

Alcohol drinker, n (%)

10 (25.0)

32 (49.2)

0.014

Hypertension, n (%)

9 (25.0)

37 (56.9)

0.001

DM, n (%)

4 (10.0)

13 (20.0)

0.177

Statin, n (%)

29 (72.5)

52 (80.0)

0.374

TG, mmol/L

1.95 ± 0.89

1.57 ± 0.7

0.025

TC, mmol/L

7.78 ± 4.01

6.14 ± 8.97

0.410

HDL-C, mmol/L

0.86 ± 0.27

0.92 ± 0.26

0.249

LDL-C, mmol/L

7.56 ± 4.49

4.61 ± 1.63

< 0.001

Lp(a), mg/dL

327.09 (107.75–532.10)

110.59 (55.03–404.98)

0.033

Xanthoma, n (%)

10 (25.0)

2 (3.1)

0.001

  1. Data are expressed as mean ± SD, or n (%). FH familial hypercholesterolemia, BMI body mass index, CAD coronary artery disease, MI myocardial infarction, DM diabetes mellitus, TG triglyceride, TC total cholesterol, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol