Skip to main content

Table 2 Biochemical and clinical characteristics of patients with different mutations

From: Application of expanded genetic analysis in the diagnosis of familial hypercholesterolemia in patients with very early-onset coronary artery disease

Characteristics FH mutation (n = 40) No FH mutation (n = 65) p value
Age, years 29.9 ± 7.57 32.78 ± 3.70 0.029
Male, n (%) 35 (87.5) 64 (98.5) 0.019
BMI, kg/(m2) 25.16 ± 5.06 31.35 ± 24.85 0.133
Family history of premature CAD, n (%) 9 (22.5) 11 (16.9) 0.480
History of MI, n (%) 21 (52.5) 31 (47.7) 0.632
Currently smoking, n (%) 20 (50.0) 50 (76.9) 0.004
Alcohol drinker, n (%) 10 (25.0) 32 (49.2) 0.014
Hypertension, n (%) 9 (25.0) 37 (56.9) 0.001
DM, n (%) 4 (10.0) 13 (20.0) 0.177
Statin, n (%) 29 (72.5) 52 (80.0) 0.374
TG, mmol/L 1.95 ± 0.89 1.57 ± 0.7 0.025
TC, mmol/L 7.78 ± 4.01 6.14 ± 8.97 0.410
HDL-C, mmol/L 0.86 ± 0.27 0.92 ± 0.26 0.249
LDL-C, mmol/L 7.56 ± 4.49 4.61 ± 1.63 < 0.001
Lp(a), mg/dL 327.09 (107.75–532.10) 110.59 (55.03–404.98) 0.033
Xanthoma, n (%) 10 (25.0) 2 (3.1) 0.001
  1. Data are expressed as mean ± SD, or n (%). FH familial hypercholesterolemia, BMI body mass index, CAD coronary artery disease, MI myocardial infarction, DM diabetes mellitus, TG triglyceride, TC total cholesterol, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol
\