Skip to main content

Table 1 Macrophage subtypes involved in aortic remodeling and aneurysm

From: Diverse roles of macrophage polarization in aortic aneurysm: destruction and repair

Disease modle/objects Pathway/key regulators References
Ang II-infused ApoE−/− mice M2 macrophage accumulation in the aortic wall Moore et al. [19]
Human aneurysmal infrarenal aortic wall M1 macrophage was predominant in the adventitia while the M2 macrophages in the intraluminal thrombus/stabilin 1 Boytard et al. [20]
Ang II-infused ApoE−/− mice Notch1 Hans et al. [21]
Cerebral aneurysms Macrophage M1/M2 imbalance and upregulation of mast cells Hasan et al. [22]
Patients with AA IL-1β was differentially expressed in human plasma with in patients with AA Batra. et al. [23]
Patients with AA NF-stimulated gene-6 (TSG-6) elevated in both the plasma and aortic wall of patients with AA Wang et al. [24]
  1. AngII angiotensin II, IL-1β interleukin-1β, ApoE apolipoprotein E, AA aortic aneurysm, TSG-6 tumor necrosis factor-inducible gene 6