Table 4 Compounds identified as potential treatment options for EMI based on CMap analysis
CMap names | Enrichment score | Dose (µM) | Cell | Up scores | Down scores |
|---|---|---|---|---|---|
LY-294002 | − 0.969 | 10 | PC3 | − 0.228 | 0.284 |
LY-294002 | − 0.968 | 10 | PC3 | − 0.307 | 0.205 |
LY-294002 | − 0.884 | 10 | HL60 | − 0.227 | 0.24 |
LY-294002 | − 0.859 | 10 | HL60 | − 0.252 | 0.202 |
Trichostatin A | − 0.847 | 1 | HL60 | − 0.229 | 0.219 |
LY-294002 | − 0.833 | 10 | HL60 | − 0.319 | 0.122 |
LY-294002 | − 0.809 | 10 | HL60 | − 0.212 | 0.215 |
SB-202190 | − 0.801 | 1 | MCF7 | − 0.149 | 0.275 |