TY - JOUR AU - Lv, Chengfang AU - Sun, Lili AU - Guo, Zhibo AU - Li, Huibo AU - Kong, Desheng AU - Xu, Bingqi AU - Lin, Leilei AU - Liu, Tianjiao AU - Guo, Dan AU - Zhou, Jin AU - Li, Yinghua PY - 2018 DA - 2018/12/17 TI - Circular RNA regulatory network reveals cell–cell crosstalk in acute myeloid leukemia extramedullary infiltration JO - Journal of Translational Medicine SP - 361 VL - 16 IS - 1 AB - Acute myeloid leukemia can develop as myoblasts infiltrate into organs and tissues anywhere other than the bone marrow, which called extramedullary infiltration (EMI), indicating a poor prognosis. Circular RNAs (circRNAs) are a novel class of non-coding RNAs that feature covalently closed continuous loops, suggesting their potential as micro RNA (miRNA) “sponges” that can participate in biological processes and pathogenesis. However, investigations on circRNAs in EMI were conducted rarely. In this study, the overall alterations of circRNAs and their regulatory network between EMI and non-EMI AML were delineated. SN - 1479-5876 UR - https://doi.org/10.1186/s12967-018-1726-x DO - 10.1186/s12967-018-1726-x ID - Lv2018 ER -