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Table 2 Comparison of incidence and hazard ratio of chronic fatigue syndrome stratified by sex, age and comorbidity between patients with and without burn

From: Increased risk of chronic fatigue syndrome following burn injuries

Variable Burn Crude HR (95% CI) Adjusted HR (95% CI)
No Yes
Event PY Rate# Event PY Rate#
All 349 405,204 0.86 140 100,663 1.39 1.61(1.53, 1.70)*** 1.48(1.41, 1.56)***
Sex
 Female 192 213,599 0.90 78 53,268 1.46 1.63(1.52, 1.75)*** 1.46(1.36, 1.56)***
 Male 157 191,605 0.82 62 47,395 1.31 1.60(1.48, 1.72)*** 1.41(1.31, 1.51)***
Age group
  ≤ 49 63 131,799 0.48 21 33,051 0.64 1.33(1.21, 1.47)*** 1.24(1.13, 1.37)***
 50–65 100 132,948 0.75 36 33,088 1.09 1.45(1.32, 1.59)*** 1.29(1.18, 1.42)***
 65+ 186 140,457 1.32 83 34,524 2.40 1.82(1.68, 1.96)*** 1.65(1.53, 1.78)***
Comorbidity
 No 205 302,276 0.68 58 66,009 0.88 1.30(1.21, 1.39)*** 1.35(1.26, 1.44)***
 Yes 144 102,928 1.40 82 34,654 2.37 1.69(1.56, 1.84)*** 1.72(1.59, 1.87)***
  1. P-values form the Cox proportional model; ***p < 0.001
  2. #Incidence rate per 1000 person-years. Multivariate analysis that includes the following variables: age, sex, and comorbidities of diabetes, obesity, renal disease, rheumatoid arthritis, HIV, malignancy, depression, anxiety, sleep disorder and irritable bowel syndrome. ‡Patients with any one of the comorbidities diabetes, obesity, renal disease, rheumatoid arthritis, HIV, malignancy, depression, anxiety, sleep disorder and irritable bowel syndrome were classified as the comorbidity group
  3. HR  hazard ratio, PY patient-year