Fig. 1

The images of MRI studies and the corresponding statistical drawing. T2-weighted MRI images show high signal lesions in the brains of the acute TLE models. The T2-weighted MRI signal intensity was slightly reduced after plain-SPION injection. The T2-weighted MRI signal intensity was decreased after anti-IL-1β-mAb-SPION injection. The T2-weighted MRI signal was significantly decreased after AMT-anti-IL-1β-mAb-SPION injection (a). The statistical analysis result was consistent with the images from MRI studies (b, *p < 0.05, **p < 0.01). There was no significant difference in the values of the T2 signals compared with those obtained pre-injection (b, p > 0.05). There was a significant difference in the T2 signal value after injection of the three types of particles (b, *p < 0.05, **p < 0.01)