Fig. 4

The ROC analysis of miRNA combinations. a–c The ROC analysis for miR-130a-3p/let-7b-5p, miR-130a-3p/miR-19b-3p, miR-130a-3p/miR-374a-5p and tumor stage were shown to distinguish responsive or poor response patients before radiation treatment. d–f The ROC analysis for the miR-130a-3p/let-7b-5p, miR-130a-3p/miR-148a-3p and tumor stage were shown to distinguish responsive or poor responsive patients after radiation treatment. Dashed line presents the ROC of tumor stage. b, e The box plots show the classifier distribution that combines the miRNA ratios with clinical data from training set. c, f The histogram shows the best accuracy of the sensitivity and specificity from the testing set. Res responsive patients, Poor poor responsive patients, Sen sensitivity, Spec specificity, AUC area under the curve