Skip to main content

Advertisement

Table 3 Logistic regression to predict non-reportable results of cfDNA testing

From: Autoimmune disorders but not heparin are associated with cell-free fetal DNA test failure

Variable N (%) or median (range) Non-reportable cfDNA assay
Univariate analysis Multivariate analysis
OR (95% CI) p OR (95% CI) p
Maternal age (years) 34 (18–49) 1.105 (1.046–1.167) < 0.001 1.006 (0.926–1.094) 0.883
Gestational age (weeks) 12.6 (11.1–27.5) 1.674 (1.436–1.953) < 0.001 1.136 (0.936–1.380) 0.198
Maternal weight (kg) 63 (43–110) 1.046 (1.028–1.065) < 0.001 1.034 (1.006–1.063) 0.017
High risk for down syndrome in maternal serum screeninga
 Yes 60 (20.1) 48.364 (21.319–109.714) < 0.001 28.823 (9.757–85.146) 0.001
 No 239 (79.9) 1   1  
IVF
 Yes 51 (16.1) 0.639 (0.273–1.499) 0.304   
 No 266 (83.9) 1    
Patients treated with LMWH
 Yes 35 (11.0) 4.555 (2.176–9.535) < 0.001 1.993 (0.539–7.377) 0.301
 No 282 (89.0) 1   1  
Patients with autoimmune disease
 Yes 12 (3.8) 9.731 (2.825–33.528) < 0.001 10.376 (1.618–66.526) 0.014
 No 305 (96.2) 1   1  
  1. Italic values indicate significance of p value (p <  0.05)
  2. LMWH low-molecular-weight heparin, IVF in vitro fertilization
  3. aMissing data in 18 cases